Emre Brookes, Mattia Rocco · Monday, 24 August 2026, 11:15 – 13:15 · Session 2
Room 101258
UltraScan SOlution MOdeler (US-SOMO)[1,2] processes atomic and lower-resolution bead model representations of biological and other macromolecules to compute various hydrodynamic parameters, such as the sedimentation and diffusion coefficients, relaxation times and intrinsic viscosity. This allows the researcher to validate structural models against experimental data. The tools available in US-SOMO have been shown to provide the best known computations of hydrodynamic parameters from experiment [3]. The US-SOMO hydrodynamics workshop will consist of two sessions. In the first session, attendees will be given an introduction to computational hydrodynamics and techniques. In the second session, users will utilize US-SOMO to compute hydrodynamics parameters from structures and to use automated batch processing to compute over multiple structures. A brief introduction to the US-SOMO web version https://somoweb.genapp.rocks will be presented. It is suggested that attendees attend both sessions, as earlier material will not be covered again during the two session course. Registered attendees will receive detailed software installation instructions in the week prior to the workshop.
References:
[1] Rocco M, Byron O., 2015, “Hydrodynamic Modeling and Its Application in AUC.”, Methods Enzymol. 2015;562:81-108. doi: 10.1016/bs.mie.2015.04.010.
[2] Rocco, M., Brookes, E. & Byron, O. US-SOMO: Methods for Construction and Hydration of Macromolecular Hydrodynamic Models. In: Encyclopedia of Biophysics, Roberts, G. & Watts, A., European Biophysical Societies (eds). Springer, Berlin, Heidelberg (2021). doi: 10.1007/978-3-642-35943-9_292-1.
[3] Brookes, E. and Rocco, M., 2018. Recent advances in the UltraScan SOlution MOdeller (US-SOMO) hydrodynamic and small-angle scattering data analysis and simulation suite. European Biophysics Journal, 47(7), pp.855-864. doi:10.1007/s00249-018-1296-0.